A control circuit suitable for a power supply. The power supply has a transformer with a primary winding and a secondary winding magnetically coupled to each other. The transformer is configured to transfer electric energy from a primary side to a secondary side and to build an output power source in the secondary side. The control circuit has a primary-side controller and a secondary-side controller. The primary-side controller is in the primary side, configured to control a current through the primary winding. In the secondary side, the secondary-side controller is powered by the output power source and configured to provide a command code with several command bits sequentially transmitted to the primary-side controller, so as to set an operation mode that the primary-side controller operates in.