In one embodiment, a system comprises: a plurality of compute nodes having a first core, a first memory, and a first fabric; a plurality of input/output (I/O) nodes having a second core, a second memory, and a second fabric and to couple to one or more I/O devices; at least one management node to receive discovery information responsive to execution of a discovery process by the plurality of compute nodes and the plurality of I/O nodes. The discovery information may include resource request information from the plurality of compute nodes and resource availability information from the plurality of I/O nodes. The at least one management node may configure the plurality of compute nodes and the plurality of I/O nodes based thereon. The system may further include an interconnection fabric to couple the plurality of compute nodes, the plurality of I/O nodes, and the at least one management node, where the at least one management node is to enable the one or more I/O devices to be shared between at least some of the plurality of compute nodes based on the discovery information. Other embodiments are described and claimed.