Invention Grant
- Patent Title: Capsid-modified rAAV vectors and methods of use
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Application No.: US14847528Application Date: 2015-09-08
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Publication No.: US09775918B2Publication Date: 2017-10-03
- Inventor: Li Zhong , Sergei Zolotukhin , Lakshmanan Govindasamy , Mavis Agbandje-McKenna , Arun Srivastava
- Applicant: University of Florida Research Foundation, Inc.
- Applicant Address: US FL Gainesville
- Assignee: University of Florida Research Foundation, Incorporated
- Current Assignee: University of Florida Research Foundation, Incorporated
- Current Assignee Address: US FL Gainesville
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C12N15/86 ; C12N15/864 ; A61K35/76 ; C12N7/00
Abstract:
Disclosed are tyrosine-modified rAAV vectors, as well as infectious virions, compositions, and pharmaceutical formulations that comprise them. Also disclosed are methods of preparing and methods for using the disclosed tyrosine-phosphorylated capsid protein mutant rAAV vectors in a variety of diagnostic and therapeutic applications including in vivo and ex vivo gene therapy, and large-scale production of rAAV vectors.
Public/Granted literature
- US20160106865A1 CAPSID-MODIFIED RAAV VECTORS AND METHODS OF USE Public/Granted day:2016-04-21
Information query
