Invention Grant
- Patent Title: Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents
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Application No.: US14911881Application Date: 2014-08-14
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Publication No.: US09777013B2Publication Date: 2017-10-03
- Inventor: Kyriacos C. Nicolaou , Min Lu , Debashis Mandal , Sanjeev Gangwar , Naidu S. Chowdari , Yam B. Poudel
- Applicant: WILLIAM MARSH RICE UNIVERSITY , BRISTOL-MYERS SQUIBB COMPANY , THE SCRIPPS RESEARCH INSTITUTE
- Applicant Address: US TX Houston US CA La Jolla US NJ Princeton
- Assignee: WILLIAM MARSH RICE UNIVERSITY,THE SCRIPPS RESEARCH INSTITUTE,BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: WILLIAM MARSH RICE UNIVERSITY,THE SCRIPPS RESEARCH INSTITUTE,BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US TX Houston US CA La Jolla US NJ Princeton
- Agency: Parker Highlander PLLC
- International Application: PCT/US2014/051127 WO 20140814
- International Announcement: WO2015/023879 WO 20150219
- Main IPC: C07D491/08
- IPC: C07D491/08 ; A61K47/48
Abstract:
In one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates comprising the compounds of formulae (I) and (II).
Public/Granted literature
- US20160185791A1 DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS Public/Granted day:2016-06-30
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