Invention Grant
- Patent Title: Compositions and methods for treatment of cytomegalovirus
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Application No.: US14357423Application Date: 2012-11-09
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Publication No.: US09777043B2Publication Date: 2017-10-03
- Inventor: David E. Anderson , Anne-Catherine Fluckiger
- Applicant: Variation Biotechnologies, Inc.
- Applicant Address: CA Ottawa
- Assignee: Variation Biotechnologies Inc.
- Current Assignee: Variation Biotechnologies Inc.
- Current Assignee Address: CA Ottawa
- Agency: Choate, Hall & Stewart LLP
- Agent Brenda Herschbach Jerrell; Rolando Medina
- International Application: PCT/IB2012/002854 WO 20121109
- International Announcement: WO2013/068847 WO 20130516
- Main IPC: C07K14/00
- IPC: C07K14/00 ; C07K14/005 ; A61K39/245 ; A61K39/00

Abstract:
The present disclosure provides compositions and methods useful for treating HCMV infection. As described herein, the compositions and methods are based on development of immunogenic compositions that include virus-like particles (VLPs) which comprise one or more Moloney Murine leukemia virus (MMLV) core proteins and include one or more HCMV epitopes, such as, for example, from HCMV envelope glycoproteins gB and/or gH and/or tegument protein pp65. Among other things, the present invention encompasses the recognition that a combination of antigens (e.g., envelope glycoproteins and structural proteins) can lead to beneficial immune responses, for example that include both a humoral response (e.g., production of neutralizing antibodies) and a cellular response (e.g., T-cell activation).
Public/Granted literature
- US20140308308A1 COMPOSITIONS AND METHODS FOR TREATMENT OF CYTOMEGALOVIRUS Public/Granted day:2014-10-16
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