A vehicle wheel service system including a plurality of sensors positioned in proximity to a heavy-duty multi-axle vehicle, to measure angles associated with three or more axles of the vehicle without repositioning the mounting of the sensors after initiating a measurement procedure. Additional sensors, associated with a vehicle reference, such as the vehicle frame axis, are disposed to provide vehicle reference measurement data which is communicated to a processing system. The processing system is configured with software instructions to evaluate the measurement data and to determine various vehicle wheel alignment angle measurements and/or necessary vehicle adjustments for each axle relative to the vehicle reference or to a fixed axle having a determined relationship to the vehicle reference.