A nuclear imaging system includes a detector configured to detect at least one photon event. A timing signal path is electrically coupled to the detector. The timing signal path is configured to generate a timing signal indicative of a timing of the at least one photon event. An energy signal path is also electrically coupled to the detector. The energy signal path is configured to generate an energy signal indicative of an energy of the at least one photon event. A time-domain multiplexer is configured combine the timing signal and the energy signal into a compound signal.