- 专利标题： Method for activating Oct4 for induction of pluripotent stem cells
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申请号： US14411506申请日： 2012-06-29
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公开(公告)号： US09783786B2公开(公告)日： 2017-10-10
- 发明人: Ralf Mrowka , Gunter Wolf , Stefan Wolfl , Xinlai Cheng
- 申请人： Ralf Mrowka , Gunter Wolf , Stefan Wolfl , Xinlai Cheng
- 申请人地址： DE Jena DE Dossenheim
- 专利权人： UNIVERSITATSKLINIKUM JENA,Stefan Wolfl
- 当前专利权人： UNIVERSITATSKLINIKUM JENA,Stefan Wolfl
- 当前专利权人地址： DE Jena DE Dossenheim
- 代理机构： JMB Davis Ben-David
- 国际申请： PCT/EP2012/062725 WO 20120629
- 国际公布： WO2014/000814 WO 20140103
- 主分类号： C12N5/02
- IPC分类号： C12N5/02 ; C12N5/074
摘要：
The invention relates to a method for inducing pluripotent stem cells, wherein a mammalian cell is contacted with a compound characterized by a general formula 1 wherein R1 is (CH2)mE, with E being CCH or CN and m being 0, 1, or 2, and R2 is selected from F, CI, Br, OR3 and R3, with R3 being selected from H, (CHyF2-y)n CHXF3-X, with n=0 or 1. The invention further relates to stem cells obtained by the method of the invention, and culture media comprising the compound of the invention.
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