A method of transmitting uplink signal through a Physical Uplink Shared Channel (PUSCH) by a mobile device in a wireless communication system. The method includes generating multiplexed information by multiplexing a first type of control information and data information; and transmitting the multiplexed information and a second type of control information through the PUSCH. One or more Resource Blocks (RBs) for the PUSCH include N Single Carrier Frequency Division Multiple Access (SC-FDMA) symbols in a slot. The multiplexed information is mapped on a first set of SC-FDMA symbols, and the first set of SC-FDMA symbols includes SC-FDMA symbols other than an (N−3)th SC-FDMA symbol for a reference signal in the slot. The second type of control information is mapped on (N−4)th and (N−2)th SC-FDMA symbols in the slot, and the second type of control information includes Acknowledgement/Negative Acknowledgement (ACK/NACK) information.