Present application provides embodiments of a transmitter and an interference cancellation method. The transmitter includes: a first digital predistorter (DPD), a power amplifier (PA), and a first processor located on a feedback channel of the transmitter and separately connected to the PA and the first DPD. The first processor performs, according to a feedback cancellation signal, interference cancellation on a signal of the feedback channel, to acquire a first mixed signal, and sends the first mixed signal to the first DPD. The first DPD is configured to perform linear predistortion processing according to a first baseband signal on a first transmit channel and the first mixed signal, to generate a first predistortion signal. The PA is configured to amplify and then transmit a to-be-transmitted signal using an antenna. The to-be-transmitted signal is the first predistortion signal or a signal obtained according to the first predistortion signal.