Invention Grant
- Patent Title: Potent and selective inhibitors of NAV1.3 and NAV1.7
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Application No.: US15134305Application Date: 2016-04-20
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Publication No.: US09796766B2Publication Date: 2017-10-24
- Inventor: Justin K. Murray , Leslie P. Miranda , Stefan I. McDonough
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Agent Angela L. Purcell
- Main IPC: C07K14/435
- IPC: C07K14/435 ; C07K14/00 ; A61K47/48 ; C07K16/44 ; A61K38/00

Abstract:
Disclosed is a composition of matter comprising an isolated polypeptide, which is a peripherally-restricted NaV1.7 inhibitor. In some disclosed embodiments, the isolated polypeptide is an inhibitor of NaV1.7 and/or NaV1.3. Other embodiments are conjugated embodiments of the inventive composition of matter and pharmaceutical compositions containing the inventive composition of matter. Isolated nucleic acids encoding some embodiments of inventive polypeptides and expression vectors, and recombinant host cells containing them are disclosed. A method of treating or preventing pain is also disclosed.
Public/Granted literature
- US20160304570A1 POTENT AND SELECTIVE INHIBITORS OF NAV1.3 AND NAV1.7 Public/Granted day:2016-10-20
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