Cutting elements for earth-boring applications may include a substrate and a polycrystalline diamond material secured to the substrate. A first region of the polycrystalline diamond material may exhibit a first volume percentage of nanoparticles bonded to diamond grains within the first region. A second region of the polycrystalline diamond material adjacent to the first region may exhibit a second, different volume percentage of nanoparticles bonded to diamond grains within the second region. Methods of making cutting elements for earth-boring applications may involve positioning a first mixture of particles having a first volume percentage of nanoparticles and a second mixture of particles having a second, different volume percentage of nanoparticles within a container. The first and second mixtures of particles may be sintered in the presence of a catalyst material to form a polycrystalline diamond material including intergranular bonds among diamond grains and nanoparticles of the polycrystalline diamond material.