A method and a system for a sign language translation and descriptive video service are disclosed. The method and system enables an easy preparation of video including a descriptive screen and a sign language so that a hearing-impaired person and a visually impaired person can receive a help for using a video media. The method includes extracting a character string in a text form from a caption of an original video; translating the character string in the text form extracted from the caption of the original video to a machine language; matching the character string translated to the machine language with a sign language video in a database; synchronizing the original video with the sign language video, and mixing the original video and the synchronized sign language video; and editing the sign language video with a sign language video editing tool.