- 专利标题: Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives
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申请号: US14904671申请日: 2014-07-14
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公开(公告)号: US09802952B2公开(公告)日: 2017-10-31
- 发明人: Daniel Kopetzki , David Tyler McQuade , Peter H. Seeberger , Kerry Gilmore
- 申请人: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
- 申请人地址: DE Munich
- 专利权人: Max-Plank-Gesellschaft zur Förderung der Wissenschaften e.V.
- 当前专利权人: Max-Plank-Gesellschaft zur Förderung der Wissenschaften e.V.
- 当前专利权人地址: DE Munich
- 代理机构: Knobbe, Martens, Olson & Bear, LLP
- 优先权: EP13176539 20130715
- 国际申请: PCT/EP2014/065053 WO 20140714
- 国际公布: WO2015/007693 WO 20150122
- 主分类号: C07D493/18
- IPC分类号: C07D493/18 ; B01J19/24
摘要:
The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C1-C5 alcohol.
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