- 专利标题： Combination of local and systemic immunomodulative therapies for melanoma and liver cancer
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申请号： US14748634申请日： 2015-06-24
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公开(公告)号： US09808524B2公开(公告)日： 2017-11-07
- 发明人: Craig J. Eagle , H. Craig Dees , Eric A. Wachter , Jamie Singer
- 申请人： Provectus Pharmaceuticals, Inc. , Pfizer, Inc.
- 申请人地址： US TN Knoxville US NY New York
- 专利权人： Provectus Pharmatech, Inc.,Pfizer, Inc.
- 当前专利权人： Provectus Pharmatech, Inc.,Pfizer, Inc.
- 当前专利权人地址： US TN Knoxville US NY New York
- 代理机构： Husch Blackwell LLP
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K31/352 ; A61K38/21 ; C07K16/30 ; A61K31/365 ; A61K38/19 ; A61K38/20 ; A61K39/00 ; A61K39/245 ; A61K45/06 ; A61K47/02 ; A61K47/60 ; C12N7/00
摘要：
A method for the treatment of cancer comprising administration of a therapeutically effective amount of an intralesional chemoablative pharmaceutical composition, or variant of said composition, in combination with a therapeutically effective amount of a systemic immunomodulatory anticancer agent. A further method for the treatment of cancer comprising administration of a therapeutically effective amount of an intralesional chemoablative pharmaceutical composition, or variant of said composition, in combination with a therapeutically effective amount of a systemic targeted anticancer agent. The present invention is further directed to pharmaceutical compositions for treatment of cancer. The intralesional chemoablative pharmaceutical composition can comprise an IL chemoablative agent comprising primarily a halogenated xanthene.