Invention Grant
- Patent Title: Pyrrolo[2,3-C]pyridines as imaging agents for neurofibrillary
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Application No.: US15317333Application Date: 2015-06-09
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Publication No.: US09808542B2Publication Date: 2017-11-07
- Inventor: Abbas W. Walji , Eric Hostetler , Thomas J. Greshock , Jing Li , Keith P. Moore , Idriss Bennacef , James Mulhearn , Harold Selnick , Yaode Wang , Kun Yang , Jianmin Fu
- Applicant: MERCK SHARP & DOHME CORP.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Sylvia A. Ayler; John C. Todaro
- Priority: WOPCT/CN2014/079834 20140613
- International Application: PCT/US2015/034794 WO 20150609
- International Announcement: WO2015/191506 WO 20151217
- Main IPC: A61K51/04
- IPC: A61K51/04 ; C07D519/00 ; C07D471/04
![Pyrrolo[2,3-C]pyridines as imaging agents for neurofibrillary](/abs-image/US/2017/11/07/US09808542B2/abs.jpg.150x150.jpg)
Abstract:
The present invention is directed to pyrrolopyridine compounds of formula (I) or their pharmaceutically acceptable salts, which may be suitable for imaging tau aggregates, b-sheet aggregates, beta-amyloid aggregates or alpha-synuclein aggregates, and hence are useful in binding and imaging tau aggregates in Alzheimer's patients. More specifically, this invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (PET) imaging to study tau deposits in brain in vivo to allow diagnosis of Alzheimer's disease and other neurodegenerative diseases characterized by tau pathology. The invention further relates to a method of measuring clinical efficacy of therapeutic agents for Alzheimer's disease and other neurodegenerative diseases characterized by tau pathology.
Public/Granted literature
- US20170119912A1 PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILLARY Public/Granted day:2017-05-04
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