Invention Grant
- Patent Title: Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trkA kinase inhibitors
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Application No.: US14442495Application Date: 2013-11-13
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Publication No.: US09809578B2Publication Date: 2017-11-07
- Inventor: Barbara J. Brandhuber , Yutong Jiang , Gabrielle R. Kolakowski , Shannon L. Winski
- Applicant: Array BioPharma Inc.
- Applicant Address: US CO Boulder
- Assignee: Array BioPharma Inc.
- Current Assignee: Array BioPharma Inc.
- Current Assignee Address: US CO Boulder
- Agency: Viksnins Harris Padys Malen LLP
- Agent Sarah S. Mastous
- International Application: PCT/US2013/069897 WO 20131113
- International Announcement: WO2014/078417 WO 20140522
- Main IPC: C07D403/14
- IPC: C07D403/14 ; C07D401/14 ; C07D403/12

Abstract:
Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.
Public/Granted literature
- US20160280690A1 PYRAZOLYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS Public/Granted day:2016-09-29
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