- 专利标题： Fused bicyclic heteroaromatic derivatives as modulators of TNF activity
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申请号： US15101283申请日： 2014-12-08
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公开(公告)号： US09815797B2公开(公告)日： 2017-11-14
- 发明人: Rikki Peter Alexander , Gregory Foulkes , Martin Clive Hutchings , Victoria Elizabeth Jackson , Boris Kroeplien , James Thomas Reuberson , Sarah Margaret Rook , Zhaoning Zhu
- 申请人： UCB BIOPHARMA SPRL
- 申请人地址： BE Brussels
- 专利权人： UCB Biopharma SPRL
- 当前专利权人： UCB Biopharma SPRL
- 当前专利权人地址： BE Brussels
- 代理机构： McDonnell Boehnen Hulbert & Berghoff LLP
- 优先权： GB1321752.6 20131209; GB1409244.9 20140523
- 国际申请： PCT/EP2014/076877 WO 20141208
- 国际公布： WO2015/086523 WO 20150618
- 主分类号： C07D239/74
- IPC分类号： C07D239/74 ; A61K31/47 ; A61K31/472 ; A61K31/498 ; A61K31/506 ; A61K31/517 ; C07D215/14 ; C07D237/28 ; A61K31/502 ; C07D215/06 ; C07D237/32 ; C07D241/44 ; A61K45/06 ; C07D217/16 ; C07D241/42 ; C07D403/04
摘要：
A series of substituted heteroaromatic compounds containing two fused six-membered rings, tivity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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