- 专利标题： 1-(triazin-3-yl/pyridazin-3-yl)-piper(-azine)idine derivatives and compositions therefor for inhibiting the activity of SHP2
-
申请号： US15110504申请日： 2015-01-16
-
公开(公告)号： US09815813B2公开(公告)日： 2017-11-14
- 发明人: Zhuoliang Chen , Michael Dore , Jorge Garcia Fortanet , Rajesh Karki , Mitsunori Kato , Matthew J. LaMarche , Lawrence Blas Perez , Sarah Williams , Martin Sendzik
- 申请人： Zhuoliang Chen , Michael Dore , Jorge Garcia Fortanet , Rajesh Karki , Mitsunori Kato , Matthew J. LaMarche , Lawrence Blas Perez , Sarah Williams , Martin Sendzik
- 申请人地址： CH Basel
- 专利权人： Novartis AG
- 当前专利权人： Novartis AG
- 当前专利权人地址： CH Basel
- 代理机构： Genomics Institute of the Novartis Research Foundation
- 代理商 Daniel E. Raymond
- 国际申请： PCT/IB2015/050344 WO 20150116
- 国际公布： WO2015/107494 WO 20150723
- 主分类号： A61K31/4427
- IPC分类号： A61K31/4427 ; C07D401/04 ; C07D401/14 ; C07D241/26 ; C07D249/14
摘要：
The present invention relates to compounds of formula I: in which Y1, Y2, Y3, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
公开/授权文献
信息查询
IPC分类:
