- 专利标题： TrkA kinase inhibitors, compositions and methods thereof
-
申请号： US15128689申请日： 2015-03-23
-
公开(公告)号： US09815846B2公开(公告)日： 2017-11-14
- 发明人: Helen Mitchell , Mark E. Fraley , Andrew J. Cooke , Craig A. Stump , Yi-Heng Chen , Xu-Fang Zhang , Casey C. McComas , Kathy Schirripa , Melody McWherter , Swati P. Mercer , Kerim Babaoglu , Dongfang Meng , Jane Wu , Ping Liu , Harold B. Wood , Jianming Bao , Chun Sing Li , Qinghua Mao , Zhiqi Qi
- 申请人： Merck Sharp & Dohme Corp. , MSD R & D (China) Co., LTD.
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Sylvia A. Ayler; John C. Todaro
- 优先权： WOPCT/CN2014/074145 20140326
- 国际申请： PCT/US2015/021936 WO 20150323
- 国际公布： WO2015/148344 WO 20151001
- 主分类号： C07D491/107
- IPC分类号： C07D491/107 ; C07C233/66 ; C07D213/75 ; C07D403/12 ; C07D401/12 ; C07D417/12 ; C07D239/42 ; C07D401/04 ; C07D413/12 ; C07D417/14 ; C07D401/14 ; C07D405/12 ; C07D413/14 ; C07D403/14 ; C07D405/14 ; C07D471/04 ; C07D401/06 ; C07D413/06 ; C07D403/06
摘要：
The present invention is directed to six membered heteroaryl benzamide compounds of formula (I), which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
公开/授权文献
- US20170114071A1 TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF 公开/授权日：2017-04-27