- 专利标题: Tricyclic sulfones as RORγ modulators
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申请号: US15148209申请日: 2016-05-06
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公开(公告)号: US09815859B2公开(公告)日: 2017-11-14
- 发明人: Jingwu Duan , T. G. Murali Dhar , David Marcoux , Qing Shi , Douglas G. Batt , Qingjie Liu , Robert J. Cherney , Lyndon A. M. Cornelius , Anurag S. Srivastava , Myra Beaudoin Bertrand , Carolyn A. Weigelt
- 申请人: BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址: US NJ Princeton
- 专利权人: Bristol-Myers Squibb Company
- 当前专利权人: Bristol-Myers Squibb Company
- 当前专利权人地址: US NJ Princeton
- 代理商 Elliott Korsen
- 主分类号: A61K31/437
- IPC分类号: A61K31/437 ; C07F9/6574 ; C07D215/36 ; C07D409/04 ; C07D417/04 ; C07D209/30 ; C07D209/60 ; C07D209/70 ; C07D221/10 ; C07D401/06 ; C07D401/12 ; C07D403/06 ; C07D403/12 ; C07D405/06 ; C07D409/06 ; C07D413/06 ; C07D413/10 ; C07D413/12 ; C07D417/06 ; C07D417/12 ; C07D417/14 ; C07D471/04 ; C07D491/052 ; C07D491/107 ; C07D493/08 ; C07D495/04 ; C07D495/08
摘要:
There are described RORγ modulators of the formula (I), and formula (II) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.
公开/授权文献
- US20160326195A1 TRICYCLIC SULFONES AS RORy MODULATORS 公开/授权日:2016-11-10
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