The present invention extends to methods, machines, systems, and computer program products for producing multiple packaging products in a tiled configuration within source production material, enabling production of multiple packaging products in parallel. Embodiments include accessing item data identifying items that are to be packaged, and determining packaging requirements for each item. A pair of box sizes that satisfy the packaging requirements are selected for tiled production. A packaging production machine to be used is also selected. Selection of the box sizes and/or the packaging production machine is based on a collective analysis of packaging requirements, packing system characteristics, and packaging machine characteristics. Based on the collective analysis, it is determined how to allocate box production to the production machine, and the pair of box sizes is matched to the production machine. Box production instructions are generated and sent to the packaging production machine.