- 专利标题: Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
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申请号: US14442503申请日: 2013-11-13
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公开(公告)号: US09822118B2公开(公告)日: 2017-11-21
- 发明人: Shelley Allen , Barbara J. Brandhuber , Kevin Ronald Condroski , Lily Huang , Timothy Kercher , Shannon L. Winski
- 申请人: Array BioPharma Inc.
- 申请人地址: US CO Boulder
- 专利权人: Array BioPharma Inc.
- 当前专利权人: Array BioPharma Inc.
- 当前专利权人地址: US CO Boulder
- 代理机构: Viksnins Harris Padys Malen LLP
- 代理商 Sarah S. Mastous
- 国际申请: PCT/US2013/069886 WO 20131113
- 国际公布: WO2014/078408 WO 20140522
- 主分类号: C07D487/04
- IPC分类号: C07D487/04 ; C07D231/56 ; C07D471/04 ; C07D491/048 ; C07D495/04 ; C07D403/12 ; C07D519/00
摘要:
Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
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