发明授权
- 专利标题： Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
-
申请号： US14399780申请日： 2013-05-06
-
公开(公告)号： US09822142B2公开(公告)日： 2017-11-21
- 发明人: Thomas Cavanagh , Shikha P. Barman , Tian Hao , Thomas B. Leland , Ritesh V. Thekkedath
- 申请人： Aciex Therapeutics, Inc.
- 申请人地址： US TX Fort Worth
- 专利权人： Nicox Ophthalmics, Inc.
- 当前专利权人： Nicox Ophthalmics, Inc.
- 当前专利权人地址： US TX Fort Worth
- 代理机构： Cooley LLP
- 代理商 Ivor R. Elrifi; Cynthia A. Kozakiewicz
- 国际申请： PCT/US2013/039694 WO 20130506
- 国际公布： WO2013/169647 WO 20131114
- 主分类号： C07J71/00
- IPC分类号： C07J71/00 ; A61K31/58 ; C07J7/00 ; C07J3/00 ; C07J31/00
摘要：
The present invention further provides method of preparing nanocrystals of a hydrophobic therapeutic agent such as fluticasone or triamcinolone, pharmaceutical compositions (e.g., topical or intranasal compositions) thereof and methods for treating and/or preventing the signs and/or symptoms of disorders such as blepharitis, meibomian gland dysfunction or skin inflammation or a respiratory disease (e.g., asthma).