A protective cover for a stethoscope comprises an elongate sleeve member having a closed first end and an open second end. The sleeve member defines an enclosed interior volume accessible via the open second end. A clip member is operatively connected to the first or second ear tube. A head and interconnecting elongate tubular body portion of the stethoscope are reposed in a position in the interior volume of the sleeve member such that the head and the body portion of the stethoscope are substantially covered. The clip member releasably holds the sleeve member in this position.