- 专利标题： Pharmaceutically acceptable salts of B-guanidinopropionic acid with improved properties and uses thereof
-
申请号： US15281329申请日： 2016-09-30
-
公开(公告)号： US09827217B2公开(公告)日： 2017-11-28
- 发明人: Eduardo J. Martinez , Andreas G. Grill , Aniruddh Singh , Padmini Kavuru
- 申请人： Rgenix, Inc.
- 申请人地址： US NY New York
- 专利权人： Rgenix, Inc.
- 当前专利权人： Rgenix, Inc.
- 当前专利权人地址： US NY New York
- 代理机构： Clark & Elbing LLP
- 代理商 Kristina Bieker-Brady
- 主分类号： A61K31/197
- IPC分类号： A61K31/197 ; A61K9/00 ; A61K47/12
摘要：
The present invention relates to new pharmaceutical salts of β-GPA which exhibit improved physical properties. In particular, the invention relates to salts of β-GPA with improved flow properties (e.g., improved Carr's index and/or Hausner ratio) such as fumarate salts, succinate salts, and oxalate salts. The invention also relates to pharmaceutical compositions including a pharmaceutically effective amount of one or more salts of β-GPA, as well as methods of treating cancer including administration of a formulation including a β-GPA salt of the invention to a subject in need thereof.
公开/授权文献
信息查询
IPC分类:
