- 专利标题： Opioid receptor modulators and use thereof
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申请号： US15207951申请日： 2016-07-12
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公开(公告)号： US09827228B2公开(公告)日： 2017-11-28
- 发明人: Shau-Hua Ueng , Shiu-Hwa Yeh , Horace Loh , Yu-Sheng Chao
- 申请人： National Health Research Institutes , Regents of the University of Minnesota
- 申请人地址： TW Zhunan Town US MN Minneapolis
- 专利权人： National Health Research Institutes,Regents of the University of Minnesota
- 当前专利权人： National Health Research Institutes,Regents of the University of Minnesota
- 当前专利权人地址： TW Zhunan Town US MN Minneapolis
- 代理机构： Cesari and McKenna, LLP
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; A61K31/422 ; A61K31/428 ; A61K31/485 ; A61K31/427 ; A61K31/4439 ; G01N33/50 ; A61K31/426 ; A61K31/454 ; G01N33/94
摘要：
Disclosed is an in vitro screening method for identifying an antagonist-to-agonist allosteric modifier of a mu-opioid receptor and an in vivo method for confirming that a test compound is such a modifier of a mu-opioid receptor. Also disclosed is a method for treating an opioid receptor-associated condition using a compound of Formula (I) and a pharmaceutical composition containing the same.
公开/授权文献
- US20170056377A1 OPIOID RECEPTOR MODULATORS AND USE THEREOF 公开/授权日：2017-03-02
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