Invention Grant
- Patent Title: Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors
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Application No.: US14770489Application Date: 2014-02-28
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Publication No.: US09828345B2Publication Date: 2017-11-28
- Inventor: Zilun Hu , Mimi L. Quan
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Hong Liu
- International Application: PCT/US2014/019242 WO 20140228
- International Announcement: WO2014/134391 WO 20140904
- Main IPC: C07D231/12
- IPC: C07D231/12 ; C07D401/12 ; C07D471/04 ; C07D403/12 ; C07D409/12 ; C07D487/04
Abstract:
The present invention provides compounds of Formula (I): (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
Public/Granted literature
- US20160002172A1 PHENYLPYRAZOLE DERIVATIVES AS POTENT ROCK1 AND ROCK2 INHIBITORS Public/Granted day:2016-01-07
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