Systems and methods for providing content-based localized brightness control are disclosed. A system may include a display panel configured to support independently controllable brightness levels for a plurality of pixel groups within the display panel. The system may also include a processor in communication with the display panel. The processor may be configured to identify a specific pixel group of the display panel based on content being displayed in the specific pixel group, and the processor may be further configured to set a brightness level of the specific pixel group differently from another pixel group of the display panel.