An adaptive envelope tracking calibration module executes a routine to calibrate a radio frequency (RF) transmitter in a communication device comprising an envelope tracking system. The routine includes receiving a selection of a calibration target power that is greater than a desired output power of the RF transmitter and determining an output power estimate for the power amplifier as a supply voltage for the power amplifier varies according to an output of the envelope tracking system. The routine further includes adaptively adjusting the calibration target power when the output power estimate is not greater than the calibration target power.