- 专利标题: Antidiabetic substituted heteroaryl compounds
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申请号: US15039607申请日: 2014-12-17
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公开(公告)号: US09834563B2公开(公告)日: 2017-12-05
- 发明人: William K. Hagmann , Bing Li , Jason W. Szewczyk , Bowei Wang , Dann Parker , Timothy Blizzard , Hubert Josien , Purakkattle Biju , Harry Chobanian , Candido Gude , Ravi P. Nargund , Barbara Pio , Qun Dang , Linus S. Lin , Bin Hu , Mingxiang Cui , Zhengxia Chen , Meibi Dai , Zaihong Zhang , Ying Lv , Lili Tian
- 申请人: Merck Sharp & Dohme Corp.
- 申请人地址: US NJ Rahway
- 专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人地址: US NJ Rahway
- 代理商 Baerbel R. Brown; Catherine D. Fitch
- 优先权: WOPCT/CN2013/090014 20131219
- 国际申请: PCT/US2014/070706 WO 20141217
- 国际公布: WO2015/095256 WO 20150625
- 主分类号: A61K31/506
- IPC分类号: A61K31/506 ; C07D493/04 ; A61K45/06 ; C07D213/64 ; A61K31/44 ; C07D409/12 ; A61K31/4436 ; C07D401/04 ; A61K31/4545 ; C07D471/04 ; A61K31/437 ; C07D405/12 ; A61K31/4433 ; C07D401/12 ; A61K31/4439 ; A61K31/443 ; C07D239/34 ; A61K31/505 ; C07D451/06 ; A61K31/46 ; C07D221/20 ; A61K31/438 ; C07D213/74 ; C07D417/04
摘要:
The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof. The compounds of formula I are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
公开/授权文献
- US20170166578A1 ANTIDIABETIC SUBSTITUTED HETEROARYL COMPOUNDS 公开/授权日:2017-06-15
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