A method, system, and computer program product for safe management of data storage using a VM are provided in the illustrative embodiments. An I/O request is received from the VM. A determination is made whether the I/O request requests a data manipulation on the data storage in an address range that overlaps with an address range of a VM signature stored on the data storage. In response to determining that the address range of the data manipulation overlaps with the address range of the VM signature, a determination is made whether an identifier of the VM matches an identifier of a second VM associated with the signature. In response to determining that the identifier of the VM does not match the identifier of the second VM, the I/O request is failed, thereby preventing an unsafe overwriting of the signature on the data storage.