- 专利标题： Piperazine derivatives as HIV protease inhibitors
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申请号： US14908421申请日： 2014-07-29
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公开(公告)号： US09840478B2公开(公告)日： 2017-12-12
- 发明人: Peter D. Williams , John A. McCauley , David Jonathan Bennett , Christopher J. Bungard , Lehua Chang , Michael P. Dwyer , M. Katharine Holloway , Kartik M. Keertikar , H. Marie Loughran , Jessie J. Manikowski , Gregori J. Morriello , Dong-Ming Shen , Edward C. Sherer , Jurgen Schultz , Sherman T. Waddell , Catherine M. Wiscount , Nicolas Zorn , Xin-Jie Chu , Satyanarayana Tummanapalli , Vijayasaradhi Sivalenka , Bin Hu , Tao Ji , Bin Zhong
- 申请人： MERCK SHARP & DOHME CORP. , MSD R&D (CHINA) CO., LTD.
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Carol S. Quagliato; Catherine D. Fitch
- 优先权： WOPCT/CN2013/000899 20130731
- 国际申请： PCT/US2014/048581 WO 20140729
- 国际公布： WO2015/017393 WO 20150205
- 主分类号： C07D241/04
- IPC分类号： C07D241/04 ; C07D401/14 ; C07D405/14 ; C07D409/14 ; C07D413/14 ; C07D401/06 ; C07D401/12 ; C07D405/12 ; C07D409/12 ; C07D417/14
摘要：
The present invention is directed to piperazine derivatives, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
公开/授权文献
- US20160159752A1 PIPERAZINE DERIVATIVES AS HIV PROTEASE INHIBITORS 公开/授权日：2016-06-09