- 专利标题： Protein kinase D inhibitors
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申请号： US13992546申请日： 2011-12-08
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公开(公告)号： US09840515B2公开(公告)日： 2017-12-12
- 发明人: Peter Wipf , Qiming Jane Wang
- 申请人： Peter Wipf , Qiming Jane Wang
- 申请人地址： US PA Pittsburgh
- 专利权人： University of Pittsburgh—Of the Commonwealth System of Higher Education
- 当前专利权人： University of Pittsburgh—Of the Commonwealth System of Higher Education
- 当前专利权人地址： US PA Pittsburgh
- 代理机构： Foley & Lardner LLP
- 国际申请： PCT/US2011/063933 WO 20111208
- 国际公布： WO2012/078859 WO 20120614
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; C07D495/04 ; C07D487/04 ; C07D491/048 ; C07D491/147 ; C07D498/04 ; C07D513/04 ; C07D513/14
摘要：
Compounds according to Formula (I), are potent inhibitors of protein kinase D (pan-PKD) activity. PKD controls key signaling cascades in cells, affecting cell proliferation, gene transcription, and protein trafficking. Accordingly, pharmaceutically acceptable compositions of the inventive compounds are candidate therapeutics for pathological conditions conditioned by changes in PKD activity.
公开/授权文献
- US20140045821A1 PROTEIN KINASE D INHIBITORS 公开/授权日：2014-02-13
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