Embodiments of the present invention provide an apparatus and a method for interference cancellation. The apparatus includes: a splitter, configured to acquire a first transmit signal and a second transmit signal; a first circulator, configured to transmit the first transmit signal to an antenna and to send a to-be-processed signal to a combiner, where the to-be-processed signal includes a receive signal component and a self-interference signal component, the self-interference signal component corresponds to an interference signal generated due to that the antenna reflects the first transmit signal; a second circulator, configured to: transmit the second transmit signal to an equivalent load, and acquire a reference signal generated due to that the equivalent load reflects the second transmit signal, where an impedance of the equivalent load corresponds to an impedance of the antenna; and a combiner, configured to cancel the self-interference signal component according to the reference signal.