A computer-implemented system and method for decoupling processing of request and response messages supporting different pluggable respective transports in a service-oriented pipeline architecture for a request-response Message Exchange Pattern (MEP) is disclosed. The method in an example embodiment includes receiving a message having coded therein information identifying a desired pluggable transport mechanism respectively for a request and a response; processing the message through a message processing pipeline; dispatching the processed message to a dispatcher; determining if the desired pluggable transport mechanism is available; activating the desired pluggable transport mechanism, if the desired pluggable transport mechanism is available; and transporting the processed message via the desired pluggable transport mechanism.