Technologies are generally provided for a tissue removal device for removing tissue protrusions extending from a wall of intestines. The tissue removal device may be a bell shaped tube configured to slide over an inflamed diverticulum that has been inverted to extend into interior space of the colon. The tissue removal device run be slid over the inverted diverticulum with a portion of the tissue removal device having a widest diameter oriented near the colon wall and a portion having a narrowest diameter oriented near a tip of the diverticulum. A pressure gradient may be induced along the walls of the tissue removal device such that the point of highest pressure at the narrowest opening may cause the walls of the diverticulum to be pinched together to induce necrosis and removal of the diverticulum, while promoting healing of the colon walls over the region of decreasing pressure.