Provided is a construction panel assembly, which is applicable to a detachable method capable of assembling and disassembling a ceiling, a wall or a floor material which partitions spaces of various kinds of buildings. Also, the construction panel assembly allows materials to be reused, so that the generation of construction waste may be minimized. The construction panel assembly includes: a main frame disposed in a mutually opposed arrangement on a wall surface at a predetermined position determined according to design specifications; an auxiliary frame inserted into the main frame to define a structure; a flat panel mounted on the structure to partition a space; and a finishing member for shielding a connection portion of the main frame and the auxiliary frame. Since the construction panel assembly may be constructed by using a main frame and an auxiliary frame, which define a structure, such that a panel formed of a material such as plate glass, a gypsum board, plywood and steel may be freely attached and detached, the materials may be reused and accordingly, the generation of the construction waste may also be minimized unlike typical techniques.