Invention Grant
- Patent Title: Compounds as TNIK, IKKε and TBK1 inhibitors and pharmaceutical composition comprising same
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Application No.: US15134987Application Date: 2016-04-21
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Publication No.: US09856216B2Publication Date: 2018-01-02
- Inventor: Soongyu Choi , Eun-Jung Park , Hee Jeong Seo , Younggyu Kong , Ickhwan Son , Sang-ho Ma , Man-Young Cha , Mi-Soon Kim , Kisoo Park
- Applicant: GREEN CROSS CORPORATION
- Applicant Address: KR Yongin-si
- Assignee: GREEN CROSS CORPORATION
- Current Assignee: GREEN CROSS CORPORATION
- Current Assignee Address: KR Yongin-si
- Agency: Sughrue Mion, PLLC
- Priority: KR10-2015-0059158 20150427
- Main IPC: C07D209/14
- IPC: C07D209/14 ; C07D209/48 ; C07D209/46 ; C07D417/04 ; C07D403/04 ; C07D401/04 ; C07D403/14 ; C07D409/12 ; C07D405/12 ; C07D409/04 ; C07D413/04 ; C07D409/14 ; C07D403/12 ; C07D405/06 ; C07D409/06 ; C07D471/04 ; C07D217/24 ; C07D401/12

Abstract:
Provided is a compound of formula (I) as a TNIK (Traf2- and NCK-interacting kinase), IKKε (I-kappa-B kinase epsilon) and TBK1 (TANK-binding kinase 1) inhibitor; the compound according to the present invention effectively inhibits TNIK, IKKε and TBK1, and thus is useful not only as an anticancer agent for the treatment of various cancers including colorectal cancer, breast cancer, CNS cancer, colon cancer, non-small cell lung cancer, kidney cancer, prostate cancer, ovarian cancer, uterus cancer, stomach cancer, liver cancer, skin cancer, lung cancer, brain cancer, bladder cancer, esophageal cancer, pancreatic cancer, thyroid cancer, head and neck cancer, squamous cell carcinoma, osteosarcoma, B-cell or T-cell lymphoma, acute or chronic leukemia and multiple myeloma, but as a therapeutic agent for chronic inflammation.
Public/Granted literature
- US20160311772A1 COMPOUNDS AS TNIK, IKKEPSILON AND TBK1 INHIBITORS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME Public/Granted day:2016-10-27
Information query