- 专利标题： Substituted quinolizine derivatives useful as HIV integrase inhibitors
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申请号： US15025038申请日： 2014-09-26
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公开(公告)号： US09861620B2公开(公告)日： 2018-01-09
- 发明人: Tao Yu , Yonglian Zhang , Sherman Tim Waddell , Andrew Stamford , John S. Wai , Paul J. Coleman , John M. Sanders , Ronald Ferguson , Thomas H. Graham , Hong Li
- 申请人： MERCK SHARP & DOHME CORP.
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Nicole M. Beeler; Catherine D. Fitch
- 国际申请： PCT/US2014/057572 WO 20140926
- 国际公布： WO2015/048363 WO 20150402
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; C07D491/02 ; C07D491/00 ; C07D221/00 ; C07D453/00 ; A61K31/4375 ; C07D455/02 ; A61K31/427 ; A61K31/4402 ; A61K31/444 ; A61K31/4745 ; A61K31/505 ; A61K31/513 ; A61K31/52 ; A61K31/635 ; A61K31/675 ; C07D455/00 ; C07D455/04 ; C07D471/14 ; C07D491/147 ; A61K45/06 ; C07D519/00
摘要：
The present invention relates to Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, R1, R2, R3, R4, R5, R9 and R10 are as defined herein. The present invention also relates to compositions comprising at least one Substituted Quinolizine Derivative, and methods of using the Substituted Quinolizine Derivatives for treating or preventing HIV infection in a subject.