The systems and methods of the present solution are directed to providing Entity Tag persistency by a device intermediary to a client and a plurality of servers. An intermediary device between a client and one or more back-end servers can receive an entity requested by the client from an origin server that provides the requested content. The intermediary device can encode the back-end server information onto an ETag of the entity, cache the entity with the encoded ETag and serve the entity with the encoded ETag to the client. In this way, when the client attempts to validate the entity by sending a request including the encoded ETag to the intermediary device, the intermediary device decodes the encoded ETag to extract the identity of the backend server and sends the request to validate the entity to the identified server that originally sent the entity that included the requested content.