A toilet flange cover system for temporarily covering a toilet flange and opening during periods of construction and remodeling when the toilet is not installed. A cover is fabricated of a rigid plastic material and formed with a generally circular shape. Diametrically opposed locking posts are integrated into the bottom of the cover having enlarged heads and can be removably received in the bolt slots for coupling the cover to a toilet flange when covering the opening and uncoupling from the toilet flange to facilitate accessing the opening. A handle aids in the coupling and uncoupling of the cover and a gasket is placed between the cover and flange to seal the opening when the cover is coupled to the toilet flange.