A color film substrate, a display panel and a display device are provided. The color film substrate comprises: a flexible base substrate partitioned to a plurality of sub-regions based on a plurality of parallel lines that is paralleled with a setting central axis of the base substrate, the plurality of sub-regions having the same area as each other; and a plurality of photo spacers provided in each of the plurality of sub-regions. For any one of the plurality of sub-regions, each of the photo spacers in one of the plurality of sub-regions is configured such that a thickness of the display panel at a position corresponding to the photo spacers is increasingly changed under the same pressure force as a distance of said one of the plurality of sub-regions from the setting central axis increases. As a result, a thickness of a liquid crystal cell of the display panel can be maintained to be uniform when the display panel is bent.