A method and apparatus for managing and controlling wireless connection of a HyperText Transfer Protocol (HTTP) proxy device in a wireless communication network are provided. The method includes receiving one of information indicating a wireless connection deactivation of an HTTP client performing HTTP communication and information indicating a change in an Internet Protocol (IP) address of the HTTP client from a predetermined node of the wireless communication network; and deactivating a connection with an HTTP server if the received information indicates the wireless connection deactivation of an HTTP client performing the HTTP communication; and maintaining a connection with an HTTP server if the received information indicates the change in the Internet Protocol (IP) address of the HTTP client.