This disclosure relates to adjusting a jitter buffer at a wireless device based on inter-arrival-jitter (IAJ). In one embodiment, an IAJ value may be calculated for each of multiple received packets. An IAJ distribution may be generated for the received packets. A target packet loss rate may be determined. A quality of service value for IAJ distributions corresponding to the target packet loss rate may be determined. A de-jitter delay value may be calculated based on the IAJ distribution and the quality of service value for IAJ distributions. The de-jitter delay value may be used to adjust the jitter buffer at the wireless device.