Embodiments of the present invention disclose a method and an apparatus for controlling uplink transmit power of UE, UE, and a base station, and the method includes: determining subframe configuration information, where the subframe configuration information is used to indicate base stations corresponding to all subframes in a radio frame; determining static power control parameters corresponding to all the base stations; determining a TPC adjustment value of a current subframe; and determining uplink transmit power of the current subframe according to a static power control parameter corresponding to a base station corresponding to the current subframe and the TPC adjustment value of the current subframe. In the embodiments of the present invention, when UE is connected to at least two base stations, control over uplink transmit power can be implemented when the UE sends data to different base stations.