- 专利标题： Substituted cinnolines as inhibitors of LRRK2 kinase activity
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申请号： US14122199申请日： 2012-05-21
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公开(公告)号： US09884828B2公开(公告)日： 2018-02-06
- 发明人: Danielle L. Aubele , Albert W. Garofalo , Simeon Bowers , Anh P. Truong , Xiaocong Michael Ye , Maurizio Franzini , Marc Adler , R. Jeffrey Neitz , Gary Probst
- 申请人： Danielle L. Aubele , Albert W. Garofalo , Simeon Bowers , Anh P. Truong , Xiaocong Michael Ye , Maurizio Franzini , Marc Adler , R. Jeffrey Neitz , Gary Probst
- 申请人地址： US WY Jackson Hole
- 专利权人： Imago Pharmaceuticals, Inc.
- 当前专利权人： Imago Pharmaceuticals, Inc.
- 当前专利权人地址： US WY Jackson Hole
- 代理机构： Fish & Richardson P.C.
- 国际申请： PCT/US2012/038871 WO 20120521
- 国际公布： WO2012/162254 WO 20121129
- 主分类号： A61K31/502
- IPC分类号： A61K31/502 ; C07D237/28 ; C07D401/04 ; C07D401/10 ; C07D401/12 ; C07D401/14 ; C07D403/04 ; C07D403/10 ; C07D405/04 ; C07D405/10 ; C07D405/12 ; C07D417/04 ; C07D413/10
摘要：
The present invention provides compounds having a structure according to Formula I: (I) or a salt or solvate thereof, wherein R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
公开/授权文献
- US20150284337A1 INHIBITORS OF LRRK2 KINASE ACTIVITY 公开/授权日：2015-10-08