Invention Grant
- Patent Title: Small molecule inhibitors of Mcl-1 and uses thereof
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Application No.: US15134098Application Date: 2016-04-20
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Publication No.: US09884841B2Publication Date: 2018-02-06
- Inventor: Zaneta Nikolovska-Coleska , Jeanne A. Stuckey , Ahmed Mady , Lei Miao
- Applicant: The Regents of the University of Michigan
- Applicant Address: US MI Ann Arbor
- Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee Address: US MI Ann Arbor
- Agency: Casimir Jones, SC
- Main IPC: A61K31/167
- IPC: A61K31/167 ; C07D333/34 ; A61K45/06 ; C07C323/63 ; C07C311/21 ; C07D295/26 ; A61K31/495 ; A61K31/18 ; A61K31/415 ; A61K31/44 ; A61K31/4409 ; A61K31/443 ; A61K31/4439 ; A61K31/451 ; A61K31/496 ; A61K31/5355 ; C07C311/29 ; C07C229/64 ; C07C233/81 ; C07C235/56
Abstract:
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having benzoic acid structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.
Public/Granted literature
- US20160304485A1 SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF Public/Granted day:2016-10-20
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