Embodiments of the present invention provide an interference suppression method and apparatus. The method includes: determining a precoding matrix according to a channel fading matrix, where the channel fading matrix is an N×M matrix, M is a quantity of antennas of a transmit end candidate device, N is a quantity of antennas of a receive end device, and each element in the channel fading matrix represents channel fading that occurs when each antenna of the transmit end candidate device transmits a signal to each antenna of the receive end device; acquiring a receiving base vector according to the precoding matrix, signal power of the transmit end candidate device, and a channel fading matrix from a signal to the receive end device; and determining receiving subspace according to the receiving base vector and receiving, in the receiving subspace, a signal sent by a transmit end selected device.