The present invention is directed towards systems and methods for multipath transmission control protocol connection (MPTCP) management. A first device, intermediary between a second device and a third device, may establish a protocol control structure responsive to establishment of a MPTCP session between the first device and the second device. The first device may maintain, via the protocol control structure, an identification of a plurality of subflows comprising transmission control protocol (TCP) connections in the MPTCP session between the first device and the second device. The first device may convert or translate, via the protocol control structure, subflow-specific sequence identifiers of packets transmitted via each of the plurality of subflows, to sequence identifiers unique across the plurality of subflows and identifying related packets from each subflows to be processed at the third device. The third device may receive the packets with the converted sequence identifiers in a single TCP connection.